| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 5 |
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| Ligand | BDBM50391643 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_847966 (CHEMBL2150266) |
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| IC50 | >10000±n/a nM |
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| Citation |  Kawakita, Y; Miwa, K; Seto, M; Banno, H; Ohta, Y; Tamura, T; Yusa, T; Miki, H; Kamiguchi, H; Ikeda, Y; Tanaka, T; Kamiyama, K; Ishikawa, T Design and synthesis of pyrrolo[3,2-d]pyrimidine HER2/EGFR dual inhibitors: improvement of the physicochemical and pharmacokinetic profiles for potent in vivo anti-tumor efficacy. Bioorg Med Chem20:6171-80 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 5 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 5 |
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| Synonyms: | MAP kinase kinase 5 | MAP2K5 | MAPK/ERK kinase 5 | MAPKK 5 | MEK5 | MKK5 | MP2K5_HUMAN | PRKMK5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50110.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1495740 |
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| Residue: | 448 |
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| Sequence: | MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ
KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV
QFNDGNAAVVSMWVCRALEERRSQQGPP
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| BDBM50391643 |
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| n/a |
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| Name | BDBM50391643 |
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| Synonyms: | CHEMBL2148052 | CHEMBL2148053 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25Cl2N5O4S |
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| Mol. Mass. | 562.468 |
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| SMILES | CC(C)(C(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(Cl)c4)c(Cl)c3)c12)S(C)(=O)=O |
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| Structure | 
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