Reaction Details |
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Target | Cytochrome P450 26A1 |
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Ligand | BDBM50391722 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_848138 (CHEMBL2148657) |
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IC50 | 9.4±n/a nM |
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Citation | Gomaa, MS; Lim, AS; Lau, SC; Watts, AM; Illingworth, NA; Bridgens, CE; Veal, GJ; Redfern, CP; Brancale, A; Armstrong, JL; Simons, C Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates. Bioorg Med Chem20:6080-8 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 26A1 |
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Name: | Cytochrome P450 26A1 |
Synonyms: | CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase |
Type: | Enzyme |
Mol. Mass.: | 56216.16 |
Organism: | Homo sapiens (Human) |
Description: | O43174 |
Residue: | 497 |
Sequence: | MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM
VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL
GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE
VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR
NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG
GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI
KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM
LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV
YPVDNLPARFTHFHGEI
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BDBM50391722 |
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n/a |
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Name | BDBM50391722 |
Synonyms: | CHEMBL2146981 |
Type | Small organic molecule |
Emp. Form. | C22H22F3N3O2 |
Mol. Mass. | 417.4242 |
SMILES | COC(=O)C(C)(C)C(c1ccc(Nc2ccc(cc2)C(F)(F)F)cc1)n1ccnc1 |
Structure |
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