| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
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| Ligand | BDBM50391730 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_848197 (CHEMBL2148933) |
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| IC50 | 37000±n/a nM |
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| Citation |  Mayadevi, M; Sherin, DR; Keerthi, VS; Rajasekharan, KN; Omkumar, RV Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II. Bioorg Med Chem20:6040-7 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium/calmodulin-dependent protein kinase type II subunit alpha |
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| Name: | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
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| Synonyms: | CAMK2A | CAMKA | CaM kinase II | CaM kinase II alpha | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2a) | KCC2A_HUMAN | KIAA0968 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54093.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_25952118 |
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| Residue: | 478 |
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| Sequence: | MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL
EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL
SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV
TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK
GAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEA
ISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIH
LMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
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| BDBM50391730 |
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| n/a |
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| Name | BDBM50391730 |
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| Synonyms: | CHEMBL258741 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H24N2O4 |
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| Mol. Mass. | 440.4905 |
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| SMILES | COc1cc(\C=C\c2cc(\C=C\c3ccc(O)c(OC)c3)n(n2)-c2ccccc2)ccc1O |
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| Structure | 
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