Reaction Details |
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Target | Cytochrome P450 2D6 |
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Ligand | BDBM50391758 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_849687 (CHEMBL2150362) |
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IC50 | >35000±n/a nM |
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Citation | Peng, H; Talreja, T; Xin, Z; Cuervo, JH; Kumaravel, G; Humora, MJ; Xu, L; Rohde, E; Gan, L; Jung, MY; Shackett, MN; Chollate, S; Dunah, AW; Snodgrass-Belt, PA; Arnold, HM; Taveras, AG; Rhodes, KJ; Scannevin, RH Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable ¿-Secretase Modulator. ACS Med Chem Lett2:786-791 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2D6 |
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Name: | Cytochrome P450 2D6 |
Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
Type: | Protein |
Mol. Mass.: | 55774.82 |
Organism: | Homo sapiens (Human) |
Description: | P10635 |
Residue: | 497 |
Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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BDBM50391758 |
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n/a |
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Name | BDBM50391758 |
Synonyms: | CHEMBL2146750 |
Type | Small organic molecule |
Emp. Form. | C29H29F4NO2 |
Mol. Mass. | 499.5397 |
SMILES | C[C@@H](C(O)=O)c1ccc([C@H](N2CCC(C)CC2)c2ccc(F)cc2)c(c1)-c1ccc(cc1)C(F)(F)F |r| |
Structure |
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