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TargetATP-sensitive inward rectifier potassium channel 1
LigandBDBM50391781
Substrate/Competitorn/a
Meas. Tech.ChEMBL_849886 (CHEMBL2148630)
IC50 30±n/a nM
Citation Tang, HWalsh, SPYan, Yde Jesus, RKShahripour, ATeumelsan, NZhu, YHa, SOwens, KAThomas-Fowlkes, BSFelix, JPLiu, JKohler, MPriest, BTBailey, TBrochu, RAlonso-Galicia, MKaczorowski, GJRoy, SYang, LMills, SGGarcia, MLPasternak, A Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics. ACS Med Chem Lett3:367-372 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
ATP-sensitive inward rectifier potassium channel 1
Name:ATP-sensitive inward rectifier potassium channel 1
Synonyms:ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:Enzyme Catalytic Domain
Mol. Mass.:44809.08
Organism:Homo sapiens (Human)
Description:gi_223460826
Residue:391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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  Blast E-value cutoff:
BDBM50391781
n/a
NameBDBM50391781
Synonyms:CHEMBL2146873 | US9073882, 38
TypeSmall organic molecule
Emp. Form.C23H24FN3O2
Mol. Mass.393.454
SMILESFc1cc(CCN2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1C#N
Structure
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