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TargetMicrosomal triglyceride transfer protein large subunit
LigandBDBM50391858
Substrate/Competitorn/a
Meas. Tech.ChEMBL_849013 (CHEMBL2150039)
IC50 0.740000±n/a nM
Citation Robinson, RPBartlett, JABertinato, PBessire, AJCosgrove, JFoley, PMManion, TBMinich, MLRamos, BReese, MRSchmahai, TJSwick, AGTess, DAVaz, AWolford, A Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. Bioorg Med Chem Lett21:4150-4 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Microsomal triglyceride transfer protein large subunit
Name:Microsomal triglyceride transfer protein large subunit
Synonyms:MTP | MTP_HUMAN | MTTP | Microsomal triglyceride transfer protein | Microsomal triglyceride transfer protein large subunit
Type:PROTEIN
Mol. Mass.:99365.65
Organism:Homo sapiens (Human)
Description:ChEMBL_971724
Residue:894
Sequence:
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS
SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ
RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA
HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL
NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG
CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV
DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG
SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA
LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR
TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM
VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH
GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA
SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN
RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF
EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
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  Blast E-value cutoff:
BDBM50391858
n/a
NameBDBM50391858
Synonyms:CHEMBL2147281
TypeSmall organic molecule
Emp. Form.C40H30F4N4O3
Mol. Mass.690.6848
SMILESCN(Cc1ccc(F)cc1)C(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2c1)c1ccccc1 |r|
Structure
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