| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxysteroid 11-beta dehydrogenase 1 |
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| Ligand | BDBM50392216 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_850498 (CHEMBL2157619) |
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| IC50 | 3770±n/a nM |
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| Citation |  Scott, JS; Bowker, SS; Deschoolmeester, J; Gerhardt, S; Hargreaves, D; Kilgour, E; Lloyd, A; Mayers, RM; McCoull, W; Newcombe, NJ; Ogg, D; Packer, MJ; Rees, A; Revill, J; Schofield, P; Selmi, N; Swales, JG; Whittamore, PR Discovery of a potent, selective, and orally bioavailable acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017). J Med Chem55:5951-64 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxysteroid 11-beta dehydrogenase 1 |
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| Name: | Hydroxysteroid 11-beta dehydrogenase 1 |
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| Synonyms: | 11-beta-hydroxysteroid dehydrogenase type 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32020.70 |
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| Organism: | Canis familiaris |
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| Description: | ChEMBL_850498 |
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| Residue: | 293 |
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| Sequence: | MAFKKKYLPPLLGFFLAYYYYSANEEFRPEMLQGKKVIVTGASKGIGEQMAYHLAKMGAH
VVVTARSKETLKKVVSHCLELGAASAHYIPGTMEDMTFAEQFVAKAGKLMGGLDMLILNH
ITNTSMNLFSGDIHLVRRSMEVNFLSYVVLSAAALPMLKQSNGSIVVVSSKAGKMSSPLV
APYSASKFALDGFFSSVRMEHSVTKVNVSITLCILGLINTDTAMKAVSGILSTVGASSKE
ECALEIIKGGALRQEEVYYDNSVWTAFLLGNPGRKILEFLSLRSYKLDKFINN
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| BDBM50392216 |
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| n/a |
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| Name | BDBM50392216 |
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| Synonyms: | CHEMBL2153191 | US8673938, 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H33N3O3S |
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| Mol. Mass. | 419.581 |
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| SMILES | CCCSc1nc(ccc1C(=O)NC1CCCCC1)N1CCC[C@@H](CC(O)=O)C1 |r| |
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| Structure | 
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