| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50392222 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_852659 (CHEMBL2156374) |
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| IC50 | 7±n/a nM |
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| Citation |  Scott, JS; Bowker, SS; Deschoolmeester, J; Gerhardt, S; Hargreaves, D; Kilgour, E; Lloyd, A; Mayers, RM; McCoull, W; Newcombe, NJ; Ogg, D; Packer, MJ; Rees, A; Revill, J; Schofield, P; Selmi, N; Swales, JG; Whittamore, PR Discovery of a potent, selective, and orally bioavailable acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017). J Med Chem55:5951-64 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32409.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28845 |
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| Residue: | 292 |
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| Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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| BDBM50392222 |
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| n/a |
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| Name | BDBM50392222 |
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| Synonyms: | CHEMBL2153178 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H26N2O2S |
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| Mol. Mass. | 346.487 |
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| SMILES | CCCSc1ncccc1C(=O)N[C@H]1[C@H]2CC3C[C@@H]1C[C@](O)(C3)C2 |r,TLB:23:20:14.13.15:17,21:20:14.13.15:17| |
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| Structure | 
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