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TargetHypoxanthine-guanine phosphoribosyltransferase
LigandBDBM50392267
Substrate/Competitorn/a
Meas. Tech.ChEMBL_850551 (CHEMBL2157773)
Ki 200±n/a nM
Citation Hocková, DKeough, DTJaneba, ZWang, THde Jersey, JGuddat, LW Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases. J Med Chem55:6209-23 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hypoxanthine-guanine phosphoribosyltransferase
Name:Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:Protein
Mol. Mass.:24579.61
Organism:Homo sapiens (Human)
Description:P00492
Residue:218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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  Blast E-value cutoff:
BDBM50392267
n/a
NameBDBM50392267
Synonyms:CHEMBL2153485
TypeSmall organic molecule
Emp. Form.C11H20N6O7P2
Mol. Mass.410.26
SMILESNc1nc2n(CCN(CCP(O)(O)=O)CCP(O)(O)=O)cnc2c(=O)[nH]1
Structure
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