Ki Summary

Reaction Details

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Target

Topoisomerase I subunit B

Ligand

BDBM50008923

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_851293 (CHEMBL2155879)

EC50

670±n/a nM

Citation

Carballeira, NM; Cartagena, M; Sanabria, D; Tasdemir, D; Prada, CF; Reguera, RM; Balaña-Fouce, R 2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani. Bioorg Med Chem Lett22:6185-9 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Topoisomerase I subunit B

Name:

Topoisomerase I subunit B

Synonyms:

DNA topoisomerase type IB small subunit | Top1B | Topoisomerase I subunit B

Type:

PROTEIN

Mol. Mass.:

28099.86

Organism:

Leishmania major

Description:

ChEMBL_851293

Residue:

262

Sequence:

MQPAQSPPVAPPSVPAAAPKKTPIDISALKLKMSPSVRATLAAAGVLGQCPRPIEAADED
ALLKLKPMKAMAPPVKKAVAPVATTAPPPKVRRVESSSSSSSGSSSSSSDDDSSRDDSSD
SDSSSYSSDDRSSSSAESVVSGEATLFHIAQSQGLVNKEILTQEEEEVPTLVPPRPPVVR
SFPNDIGKALERYRERLNREENIIRIKDDNKAVSLGTSKINYIDPRIICSWAKAQDVPIN
KIFSATIQKKFPWAMNAENFDF

BDBM50008923

n/a

Name

BDBM50008923

Synonyms:

(S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]florene-3,13-dione | (S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (CPT, Camptothecin) | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (Camptothecin) | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (camptothecin or CPT) | 4-ethyl-4-hydroxy-(4S)-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione | CHEMBL65 | Camptothecin (CT) | camptothecine | cid_24360

Type

Small organic molecule

Emp. Form.

C20H16N2O4

Mol. Mass.

348.352

SMILES

CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O |r|

Structure