Reaction Details |
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Target | Asparagine synthetase [glutamine-hydrolyzing] |
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Ligand | BDBM50392270 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_851326 (CHEMBL2156033) |
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Ki | 8±n/a nM |
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Citation | Ikeuchi, H; Ahn, YM; Otokawa, T; Watanabe, B; Hegazy, L; Hiratake, J; Richards, NG A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells. Bioorg Med Chem20:5915-27 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Asparagine synthetase [glutamine-hydrolyzing] |
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Name: | Asparagine synthetase [glutamine-hydrolyzing] |
Synonyms: | ASNS | ASNS_HUMAN | Asparagine synthetase | TS11 |
Type: | PROTEIN |
Mol. Mass.: | 64373.20 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_851327 |
Residue: | 561 |
Sequence: | MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQ
PIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEIILHLYDKGGIEQTICMLDGV
FAFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPF
LPGHYEVLDLKPNGKVASVEMVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFN
NAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAAR
KVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVV
IFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPF
LDHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNS
WFKILQEYVEHQVDDAMMANAAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPK
WINATDPSARTLTHYKSAVKA
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BDBM50392270 |
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n/a |
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Name | BDBM50392270 |
Synonyms: | CHEMBL2153507 |
Type | Small organic molecule |
Emp. Form. | C13H22N7O7PS |
Mol. Mass. | 451.395 |
SMILES | CS(=O)(NP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)=CC[NH3+] |r| |
Structure |
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