| Reaction Details |
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 | Report a problem with these data |
| Target | KiSS-1 receptor |
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| Ligand | BDBM50392486 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_852184 (CHEMBL2157605) |
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| EC50 | 0.039±n/a nM |
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| Citation |  Asami, T; Nishizawa, N; Ishibashi, Y; Nishibori, K; Horikoshi, Y; Matsumoto, H; Ohtaki, T; Kitada, C Trypsin resistance of a decapeptide KISS1R agonist containing an N¿-methylarginine substitution. Bioorg Med Chem Lett22:6328-32 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| KiSS-1 receptor |
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| Name: | KiSS-1 receptor |
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| Synonyms: | AXOR12 | G-protein Coupled Receptor 54 | G-protein coupled receptor 54 (GPR54) | GPR54 | Hypogonadotropin-1 | KISS1R | KISSR_HUMAN | KiSS-1R | Kisspeptins receptor | Metastin receptor | hOT7T175 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42613.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assay was performed using membranes from the CHO cell transfectants. |
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| Residue: | 398 |
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| Sequence: | MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGN
SLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNY
IQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLAL
HRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAP
ADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYA
AYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPH
AELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL
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| BDBM50392486 |
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| n/a |
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| Name | BDBM50392486 |
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| Synonyms: | CHEMBL2152056 |
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| Type | Small organic molecule |
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| Emp. Form. | C65H87N17O14 |
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| Mol. Mass. | 1330.4918 |
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| SMILES | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N(C)C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r,w:76.79| |
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| Structure | 
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