Ki Summary

Reaction Details

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Target

KiSS-1 receptor

Ligand

BDBM50392487

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_852184 (CHEMBL2157605)

EC50

0.32±n/a nM

Citation

Asami, T; Nishizawa, N; Ishibashi, Y; Nishibori, K; Horikoshi, Y; Matsumoto, H; Ohtaki, T; Kitada, C Trypsin resistance of a decapeptide KISS1R agonist containing an N¿-methylarginine substitution. Bioorg Med Chem Lett22:6328-32 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

KiSS-1 receptor

Name:

KiSS-1 receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

42613.79

Organism:

Homo sapiens (Human)

Description:

Binding assay was performed using membranes from the CHO cell transfectants.

Residue:

398

Sequence:

MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGN
SLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNY
IQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLAL
HRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAP
ADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYA
AYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPH
AELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL

BDBM50392487

n/a

Name

BDBM50392487

Synonyms:

CHEMBL2152057

Type

Small organic molecule

Emp. Form.

C65H87N17O14

Mol. Mass.

1330.4918

SMILES

CNC(NC)=NCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r,wU:72.75,50.63,36.39,9.9,wD:64.71,42.47,25.33,13.17,85.88,(24.46,-25.66,;24.45,-27.2,;25.79,-27.98,;27.13,-27.21,;28.47,-27.98,;25.79,-29.53,;24.45,-30.3,;24.45,-31.85,;23.11,-32.62,;23.1,-34.17,;21.76,-34.94,;20.44,-34.17,;20.44,-32.63,;19.1,-34.94,;19.1,-36.48,;20.44,-37.25,;20.44,-38.79,;21.76,-36.48,;17.77,-34.17,;16.44,-34.94,;16.44,-36.48,;15.1,-34.17,;13.78,-34.94,;12.44,-34.17,;12.44,-32.63,;11.11,-34.94,;11.11,-36.48,;12.44,-37.25,;13.78,-36.48,;15.11,-37.25,;15.11,-38.79,;13.78,-39.56,;12.44,-38.78,;9.77,-34.17,;8.45,-34.94,;8.45,-36.48,;7.11,-34.17,;7.11,-32.63,;8.45,-31.87,;5.77,-34.94,;4.44,-34.17,;4.44,-32.63,;3.11,-34.94,;3.11,-36.48,;4.44,-37.25,;5.77,-36.48,;4.44,-38.79,;1.78,-34.17,;.44,-34.94,;.44,-36.48,;-.9,-34.17,;-.9,-32.63,;.44,-31.86,;1.85,-32.49,;2.87,-31.34,;2.11,-30.01,;2.58,-28.55,;1.56,-27.4,;.05,-27.73,;-.43,-29.19,;.6,-30.32,;-2.22,-34.94,;-3.56,-34.17,;-3.56,-32.63,;-4.89,-34.94,;-4.89,-36.48,;-3.56,-37.25,;-2.22,-36.48,;-3.56,-38.79,;-6.22,-34.17,;-7.56,-34.94,;-7.56,-36.48,;-8.89,-34.17,;-10.22,-34.94,;-8.89,-32.63,;-7.56,-31.86,;-6.22,-32.63,;-4.89,-31.86,;-4.89,-30.33,;-3.56,-29.55,;-6.22,-29.55,;-7.56,-30.32,;24.44,-34.94,;24.44,-36.48,;25.77,-34.17,;27.1,-34.94,;27.1,-36.48,;28.43,-37.25,;29.77,-36.48,;31.11,-37.25,;31.11,-38.79,;29.77,-39.56,;28.43,-38.78,;28.43,-34.17,;29.77,-34.94,;28.43,-32.63,)|

Structure