Reaction Details |
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Target | Cholesteryl ester transfer protein |
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Ligand | BDBM50392517 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_852276 (CHEMBL2155542) |
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IC50 | 7±n/a nM |
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Citation | Miller, MM; Liu, Y; Jiang, J; Johnson, JA; Kamau, M; Nirschl, DS; Wang, Y; Harikrishnan, L; Taylor, DS; Chen, AY; Yin, X; Seethala, R; Peterson, TL; Zvyaga, T; Zhang, J; Huang, CS; Wexler, RR; Poss, MA; Lawrence, RM; Adam, LP; Salvati, ME Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors. Bioorg Med Chem Lett22:6503-8 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cholesteryl ester transfer protein |
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Name: | Cholesteryl ester transfer protein |
Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
Type: | Enzyme |
Mol. Mass.: | 54751.53 |
Organism: | Homo sapiens (Human) |
Description: | P11597 |
Residue: | 493 |
Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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BDBM50392517 |
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n/a |
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Name | BDBM50392517 |
Synonyms: | CHEMBL2152170 |
Type | Small organic molecule |
Emp. Form. | C26H21ClF7N3O2 |
Mol. Mass. | 575.906 |
SMILES | FC(F)C(F)(F)Oc1cc(F)cc(c1)[C@](Cc1ccccc1)(NC(=O)NC1CC(F)(F)C1)c1ccc(Cl)cn1 |r| |
Structure |
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