| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine synthase |
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| Ligand | BDBM50392652 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_854111 (CHEMBL2153942) |
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| IC50 | 1430±n/a nM |
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| Citation |  Zhang, Z; Tian, C; Zhou, S; Wang, W; Guo, Y; Xia, J; Liu, Z; Wang, B; Wang, X; Golding, BT; Griff, RJ; Du, Y; Liu, J Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents. Eur J Med Chem58:228-36 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine synthase |
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| Name: | Methionine synthase |
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| Synonyms: | 5-methyltetrahydrofolate--homocysteine methyltransferase | METH_HUMAN | MS | MTR | Vitamin-B12 dependent methionine synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 140503.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_854111 |
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| Residue: | 1265 |
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| Sequence: | MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHA
RPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMC
SAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA
KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQT
GEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDET
PSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGL
EPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDG
MLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDD
FLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNI
LTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLY
HAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKV
IQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVG
DLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATV
KGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEM
IFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDEN
LKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQV
FEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTL
ISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYY
CLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEE
LHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTG
IRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPIL
GYDTD
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| BDBM50392652 |
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| n/a |
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| Name | BDBM50392652 |
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| Synonyms: | CHEMBL2153714 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28Br3N7O5 |
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| Mol. Mass. | 722.224 |
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| SMILES | Nc1nc(N)c2N(CC(Br)CBr)C(CNc3ccc(cc3Br)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CCc2n1 |r| |
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| Structure | 
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