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TargetNeutrophil collagenase
LigandBDBM50392686
Substrate/Competitorn/a
Meas. Tech.ChEMBL_854274 (CHEMBL2154440)
IC50 336±n/a nM
Citation Nicolotti, OCatto, MGiangreco, IBarletta, MLeonetti, FStefanachi, APisani, LCellamare, STortorella, PLoiodice, FCarotti, A Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9. Eur J Med Chem58:368-76 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neutrophil collagenase
Name:Neutrophil collagenase
Synonyms:CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:Enzyme
Mol. Mass.:53413.48
Organism:Homo sapiens (Human)
Description:P22894
Residue:467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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  Blast E-value cutoff:
BDBM50392686
n/a
NameBDBM50392686
Synonyms:CHEMBL2151355
TypeSmall organic molecule
Emp. Form.C19H16N2O5
Mol. Mass.352.3407
SMILESCc1ccc(cc1)-c1ccc(cc1)C(=O)CC1(O)C(=O)NC(=O)NC1=O
Structure
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