Reaction Details |
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Target | Neutrophil collagenase |
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Ligand | BDBM50392686 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_854274 (CHEMBL2154440) |
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IC50 | 336±n/a nM |
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Citation | Nicolotti, O; Catto, M; Giangreco, I; Barletta, M; Leonetti, F; Stefanachi, A; Pisani, L; Cellamare, S; Tortorella, P; Loiodice, F; Carotti, A Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9. Eur J Med Chem58:368-76 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil collagenase |
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Name: | Neutrophil collagenase |
Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
Type: | Enzyme |
Mol. Mass.: | 53413.48 |
Organism: | Homo sapiens (Human) |
Description: | P22894 |
Residue: | 467 |
Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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BDBM50392686 |
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n/a |
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Name | BDBM50392686 |
Synonyms: | CHEMBL2151355 |
Type | Small organic molecule |
Emp. Form. | C19H16N2O5 |
Mol. Mass. | 352.3407 |
SMILES | Cc1ccc(cc1)-c1ccc(cc1)C(=O)CC1(O)C(=O)NC(=O)NC1=O |
Structure |
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