| Reaction Details |
|---|
 | Report a problem with these data |
| Target | SRC |
|---|
| Ligand | BDBM50392791 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_853155 |
|---|
| IC50 | 2.2±n/a nM |
|---|
| Citation |  Wang T; Lamb ML; Block MH; Davies AM; Han Y; Hoffmann E; Ioannidis S; Josey JA; Liu ZY; Lyne PD; MacIntyre T; Mohr PJ; Omer CA; Sjögren T; Thress K; Wang B; Wang H; Yu D; Zhang HJ Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett 3:705-709 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| SRC |
|---|
| Name: | SRC |
|---|
| Synonyms: | FGR | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Tyrosine-protein kinase Fgr | Tyrosine-protein kinase Fgr |
|---|
| Type: | protein |
|---|
| Mol. Mass.: | 59469.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P09769 |
|---|
| Residue: | 529 |
|---|
| Sequence: | MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA
INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL
SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY
SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP
CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP
KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV
DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF
PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP
PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
|
|
|
|---|
| BDBM50392791 |
|---|
| n/a |
|---|
| Name | BDBM50392791 |
|---|
| Synonyms: | CHEMBL2151321 | US8486966, 1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H20FN7O |
|---|
| Mol. Mass. | 381.4068 |
|---|
| SMILES | CC(C)Oc1cc(n[nH]1)-n1cnc2ccc(N[C@@H](C)c3ccc(F)cn3)nc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
