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TargetPhosphorylase kinase
LigandBDBM50392791
Substrate/Competitorn/a
Meas. Tech.ChEMBL_853158
IC50 6.1±n/a nM
Citation Wang TLamb MLBlock MHDavies AMHan YHoffmann EIoannidis SJosey JALiu ZYLyne PDMacIntyre TMohr PJOmer CASjögren TThress KWang BWang HYu DZhang HJ Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett 3:705-709 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Phosphorylase kinase
Name:Phosphorylase kinase
Synonyms:PHKG2 | Phosphorylase kinase gamma subunit 2
Type:PROTEIN
Mol. Mass.:46440.15
Organism:Homo sapiens (Human)
Description:ChEMBL_774277
Residue:406
Sequence:
MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAE
RLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLT
EKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEP
GEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL
MLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPW
NLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGH
WVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG
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BDBM50392791
n/a
NameBDBM50392791
Synonyms:CHEMBL2151321 | US8486966, 1
TypeSmall organic molecule
Emp. Form.C19H20FN7O
Mol. Mass.381.4068
SMILESCC(C)Oc1cc(n[nH]1)-n1cnc2ccc(N[C@@H](C)c3ccc(F)cn3)nc12 |r|
Structure
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