| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-glutamine gamma-glutamyltransferase K |
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| Ligand | BDBM50392881 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_853390 (CHEMBL2155210) |
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| IC50 | 910±n/a nM |
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| Citation |  Prime, ME; Brookfield, FA; Courtney, SM; Gaines, S; Marston, RW; Ichihara, O; Li, M; Vaidya, D; Williams, H; Pedret-Dunn, A; Reed, L; Schaertl, S; Toledo-Sherman, L; Beconi, M; Macdonald, D; Muņoz-Sanjuan, I; Dominguez, C; Wityak, J Irreversible 4-Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease. ACS Med Chem Lett3:731-735 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-glutamine gamma-glutamyltransferase K |
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| Name: | Protein-glutamine gamma-glutamyltransferase K |
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| Synonyms: | KTG | Protein-glutamine gamma-glutamyltransferase K | TGM1 | TGM1_HUMAN | Transglutaminase-1 (TG1) |
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| Type: | Protein |
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| Mol. Mass.: | 89778.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 817 |
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| Sequence: | MMDGPRSDVGRWGGNPLQPPTTPSPEPEPEPDGRSRRGGGRSFWARCCGCCSCRNAADDD
WGPEPSDSRGRGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGMLVVNGVDLLSS
RSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYESSDRITLELLIGNNPEVGKGTH
VIIPVGKGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAGEFQLPFDPR
NEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDA
CLYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSVE
ILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDEN
MKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESI
KNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMREDI
TYLYKHPEGSDAERKAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAVMGQDLMVSVML
INHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLV
DQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPVT
LTNVVFRLEGSGLQRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHG
VIQVDVAPAPGDGGFFSDAGGDSHLGETIPMASRGGA
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| BDBM50392881 |
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| n/a |
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| Name | BDBM50392881 |
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| Synonyms: | CHEMBL2152090 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25N3O5S |
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| Mol. Mass. | 443.516 |
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| SMILES | C=CC(=O)NC1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)OCc2ccccc2)cc1 |
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| Structure | 
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