| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-glutamine gamma-glutamyltransferase 2 |
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| Ligand | BDBM50392906 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_853394 (CHEMBL2155214) |
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| IC50 | 55±n/a nM |
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| Citation |  Prime, ME; Brookfield, FA; Courtney, SM; Gaines, S; Marston, RW; Ichihara, O; Li, M; Vaidya, D; Williams, H; Pedret-Dunn, A; Reed, L; Schaertl, S; Toledo-Sherman, L; Beconi, M; Macdonald, D; Muņoz-Sanjuan, I; Dominguez, C; Wityak, J Irreversible 4-Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease. ACS Med Chem Lett3:731-735 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-glutamine gamma-glutamyltransferase 2 |
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| Name: | Protein-glutamine gamma-glutamyltransferase 2 |
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| Synonyms: | TG(C) | TGC | TGM2_MOUSE | TGase C | TGase-2 | Tgm2 | Tissue transglutaminase | Transglutaminase C | Transglutaminase-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 77039.00 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_841041 |
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| Residue: | 686 |
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| Sequence: | MAEELLLERCDLEIQANGRDHHTADLCQEKLVLRRGQRFRLTLYFEGRGYEASVDSLTFG
AVTGPDPSEEAGTKARFSLSDNVEEGSWSASVLDQQDNVLSLQLCTPANAPIGLYRLSLE
ASTGYQGSSFVLGHFILLYNAWCPADDVYLDSEEERREYVLTQQGFIYQGSVKFIKSVPW
NFGQFEDGILDTCLMLLDMNPKFLKNRSRDCSRRSSPIYVGRVVSAMVNCNDDQGVLLGR
WDNNYGDGISPMAWIGSVDILRRWKEHGCQQVKYGQCWVFAAVACTVLRCLGIPTRVVTN
YNSAHDQNSNLLIEYFRNEFGELESNKSEMIWNFHCWVESWMTRPDLQPGYEGWQAIDPT
PQEKSEGTYCCGPVSVRAIKEGDLSTKYDAPFVFAEVNADVVDWIRQEDGSVLKSINRSL
VVGQKISTKSVGRDDREDITHTYKYPEGSPEEREVFTKANHLNKLAEKEETGVAMRIRVG
DSMSMGNDFDVFAHIGNDTSETRECRLLLCARTVSYNGVLGPECGTEDINLTLDPYSENS
IPLRILYEKYSGCLTESNLIKVRGLLIEPAANSYLLAERDLYLENPEIKIRVLGEPKQNR
KLVAEVSLKNPLSDPLYDCIFTVEGAGLTKEQKSVEVSDPVPAGDLVKARVDLFPTDIGL
HKLVVNFQCDKLKSVKGYRNVIIGPA
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| BDBM50392906 |
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| n/a |
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| Name | BDBM50392906 |
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| Synonyms: | CHEMBL2152204 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29N3O5S |
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| Mol. Mass. | 471.569 |
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| SMILES | COc1ccc(CCNC(=O)c2ccc(cc2)S(=O)(=O)N2CCC(CC2)NC(=O)C=C)cc1 |
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| Structure | 
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