Reaction Details | |||
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Target | Mitogen-activated protein kinase 8 | ||
Ligand | BDBM50392987 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_853501 (CHEMBL2153878) | ||
IC50 | 54±n/a nM | ||
Citation | Haynes, NE; Scott, NR; Chen, LC; Janson, CA; Li, JK; Lukacs, CM; Railkar, A; Tozzo, E; Whittard, T; Brown, NF; Cheung, AW Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor. ACS Med Chem Lett3:764-768 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase 8 | |||
Name: | Mitogen-activated protein kinase 8 | ||
Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) | ||
Type: | Enzyme | ||
Mol. Mass.: | 48297.57 | ||
Organism: | Homo sapiens (Human) | ||
Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). | ||
Residue: | 427 | ||
Sequence: |
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BDBM50392987 | |||
n/a | |||
Name | BDBM50392987 | ||
Synonyms: | CHEMBL2152387 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H29N3O5 | ||
Mol. Mass. | 511.5684 | ||
SMILES | COC(=O)c1c(Cc2ccc(cc2)C(=O)N[C@H]2CC[C@H](O)CC2)c(=O)c2cccnc2n1-c1ccccc1 |r,wU:16.16,wD:19.20,(13.6,-20.56,;12.27,-19.79,;12.27,-18.25,;13.61,-17.48,;10.94,-17.47,;10.94,-15.92,;12.28,-15.15,;12.27,-13.61,;13.61,-12.85,;13.61,-11.31,;12.28,-10.54,;10.94,-11.31,;10.95,-12.85,;12.28,-9,;13.61,-8.23,;10.94,-8.23,;10.94,-6.69,;9.61,-5.93,;9.61,-4.38,;10.95,-3.61,;10.95,-2.07,;12.28,-4.39,;12.28,-5.92,;9.59,-15.13,;9.59,-13.59,;8.25,-15.91,;6.92,-15.15,;5.59,-15.92,;5.59,-17.47,;6.92,-18.24,;8.25,-17.47,;9.59,-18.24,;9.59,-19.78,;8.25,-20.54,;8.24,-22.08,;9.58,-22.86,;10.92,-22.08,;10.91,-20.55,)| | ||
Structure |