| Reaction Details |
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 | Report a problem with these data |
| Target | Multidrug and toxin extrusion protein 2 |
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| Ligand | BDBM50010859 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_852940 (CHEMBL2154124) |
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| IC50 | >100000±n/a nM |
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| Citation |  Kido, Y; Matsson, P; Giacomini, KM Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. J Med Chem54:4548-58 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Multidrug and toxin extrusion protein 2 |
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| Name: | Multidrug and toxin extrusion protein 2 |
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| Synonyms: | Kidney-specific H(+)/organic cation antiporter | MATE-2 | MATE2 | S47A2_HUMAN | SLC47A2 | Solute carrier family 47 member 2 | hMATE-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65098.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_934314 |
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| Residue: | 602 |
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| Sequence: | MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCG
HLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVLL
LCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWL
KGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSV
LNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSML
MICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAAD
TVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVF
EAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFL
ATAAFVAYTARLDWKLAAEEAKKHSGRQQQQRAESTATRPGPEKAVLSSVATGSSPGITL
TTYSRSECHVDFFRTPEEAHALSAPTSRLSVKQLVIRRGAALGAASATLMVGLTVRILAT
RH
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| BDBM50010859 |
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| n/a |
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| Name | BDBM50010859 |
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| Synonyms: | CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE PAMOATE | Imipramin |
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| Type | Small organic molecule |
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| Emp. Form. | C19H24N2 |
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| Mol. Mass. | 280.4073 |
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| SMILES | CN(C)CCCN1c2ccccc2CCc2ccccc12 |
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| Structure | 
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