| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
|---|
| Ligand | BDBM50393512 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_856427 |
|---|
| EC50 | 270±n/a nM |
|---|
| Citation |  Day JP; Lindsay B; Riddell T; Jiang Z; Allcock RW; Abraham A; Sookup S; Christian F; Bogum J; Martin EK; Rae RL; Anthony D; Rosair GM; Houslay DM; Huston E; Baillie GS; Klussmann E; Houslay MD; Adams DR Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). J Med Chem 54:3331-47 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
|---|
| Name: | Phosphodiesterase 4 and 5 (PDE4 and PDE5) |
|---|
| Synonyms: | DPDE2 | PDE46 | PDE4A | Phosphodiesterase 4A (PDE4) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 98113.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P27815 |
|---|
| Residue: | 886 |
|---|
| Sequence: | MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ
PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR
SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP
FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW
CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI
PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD
QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML
TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV
SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM
VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE
LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL
VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE
ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT
QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP
STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
|
|
|
|---|
| BDBM50393512 |
|---|
| n/a |
|---|
| Name | BDBM50393512 |
|---|
| Synonyms: | CHEMBL2158057 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14ClN3O |
|---|
| Mol. Mass. | 311.766 |
|---|
| SMILES | Clc1cccc(c1)-c1nn(CC2CC2)c(=O)c2cccnc12 |
|---|
| Structure | 
|
|---|
Search and Browse
