Reaction Details |
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Target | Glucagon receptor |
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Ligand | BDBM50360601 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_857255 (CHEMBL2160600) |
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IC50 | 122±n/a nM |
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Citation | Xiong, Y; Guo, J; Candelore, MR; Liang, R; Miller, C; Dallas-Yang, Q; Jiang, G; McCann, PE; Qureshi, SA; Tong, X; Xu, SS; Shang, J; Vincent, SH; Tota, LM; Wright, MJ; Yang, X; Zhang, BB; Tata, JR; Parmee, ER Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-ß-alanine (MK-0893) for the treatment of type II diabetes. J Med Chem55:6137-48 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glucagon receptor |
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Name: | Glucagon receptor |
Synonyms: | GL-R | GLR_MOUSE | Gcgr |
Type: | PROTEIN |
Mol. Mass.: | 54941.21 |
Organism: | Mus musculus |
Description: | ChEMBL_1338729 |
Residue: | 485 |
Sequence: | MPLTQLHCPHLLLLLLVLSCLPEAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCN
RTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQPWRNAS
QCQLDDEEIEVQKGVAKMYSSQQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGN
LFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAMAGCRVATVIMQYGIIANY
CWLLVEGVYLYSLLSLATFSERSFFSLYLGIGWGAPLLFVIPWVVVKCLFENVQCWTSND
NMGFWWILRIPVFLALLINFFIFVHIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLG
VHEVVFAFVTDEHAQGTLRSTKLFFDLFLSSFQGLLVAVLYCFLNKEVQAELMRRWRQWQ
EGKALQEERLASSHGSHMAPAGPCHGDPCEKLQLMSAGSSSGTGCVPSMETSLASSLPRL
ADSPT
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BDBM50360601 |
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n/a |
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Name | BDBM50360601 |
Synonyms: | CHEMBL1933349 | MK-0893 |
Type | Small organic molecule |
Emp. Form. | C32H27Cl2N3O4 |
Mol. Mass. | 588.48 |
SMILES | COc1ccc2cc(ccc2c1)-c1cc(nn1[C@@H](C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1 |r| |
Structure |
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