Ki Summary

Reaction Details

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Target

Vasoactive intestinal polypeptide receptor 1

Ligand

BDBM50360601

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_857262 (CHEMBL2160607)

IC50

11580±n/a nM

Citation

Xiong, Y; Guo, J; Candelore, MR; Liang, R; Miller, C; Dallas-Yang, Q; Jiang, G; McCann, PE; Qureshi, SA; Tong, X; Xu, SS; Shang, J; Vincent, SH; Tota, LM; Wright, MJ; Yang, X; Zhang, BB; Tata, JR; Parmee, ER Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-ß-alanine (MK-0893) for the treatment of type II diabetes. J Med Chem55:6137-48 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Vasoactive intestinal polypeptide receptor 1

Name:

Vasoactive intestinal polypeptide receptor 1

Synonyms:

VIP 1 | VIPR1 | VIPR1_HUMAN | Vasoactive intestinal polypeptide receptor 1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

51557.18

Organism:

Homo sapiens (Human)

Description:

VIP 1 VIPR1 0::P32241

Residue:

457

Sequence:

MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENET
IGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPI
ACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMH
LFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYL
YTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSLWWIIKGP
ILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFF
PDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRH
PSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV

BDBM50360601

n/a

Name

BDBM50360601

Synonyms:

CHEMBL1933349 | MK-0893

Type

Small organic molecule

Emp. Form.

C32H27Cl2N3O4

Mol. Mass.

588.48

SMILES

COc1ccc2cc(ccc2c1)-c1cc(nn1[C@@H](C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1 |r|

Structure