Reaction Details |
| Report a problem with these data |
Target | Methionine--tRNA ligase, cytoplasmic |
---|
Ligand | BDBM50393793 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_854755 (CHEMBL2161886) |
---|
IC50 | 4246±n/a nM |
---|
Citation | Shibata, S; Gillespie, JR; Ranade, RM; Koh, CY; Kim, JE; Laydbak, JU; Zucker, FH; Hol, WG; Verlinde, CL; Buckner, FS; Fan, E Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. J Med Chem55:6342-51 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Methionine--tRNA ligase, cytoplasmic |
---|
Name: | Methionine--tRNA ligase, cytoplasmic |
Synonyms: | MARS | MARS1 | Methionyl-tRNA synthetase | SYMC_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 101110.04 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_105283 |
Residue: | 900 |
Sequence: | MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLF
STSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRA
LTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQE
PCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAW
EKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRL
RQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTP
QQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDK
CGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQF
ITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWW
KNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGV
GVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMF
VSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQ
VNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSI
LLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQ
QIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
|
|
|
BDBM50393793 |
---|
n/a |
---|
Name | BDBM50393793 |
Synonyms: | CHEMBL2159527 |
Type | Small organic molecule |
Emp. Form. | C17H18Cl2FN3O |
Mol. Mass. | 370.249 |
SMILES | Fc1cccc(NC(=O)NCCCNCc2cc(Cl)cc(Cl)c2)c1 |
Structure |
|