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TargetMethionyl-tRNA synthetase
LigandBDBM50393800
Substrate/Competitorn/a
Meas. Tech.ChEMBL_854755
IC50 6591±n/a nM
Citation Shibata SGillespie JRRanade RMKoh CYKim JELaydbak JUZucker FHHol WGVerlinde CLBuckner FSFan E Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. J Med Chem 55:6342-51 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methionyl-tRNA synthetase
Name:Methionyl-tRNA synthetase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:101110.04
Organism:Homo sapiens (Human)
Description:ChEMBL_105283
Residue:900
Sequence:
MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLF
STSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRA
LTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQE
PCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAW
EKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRL
RQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTP
QQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDK
CGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQF
ITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWW
KNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGV
GVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMF
VSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQ
VNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSI
LLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQ
QIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
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  Blast E-value cutoff:
BDBM50393800
n/a
NameBDBM50393800
Synonyms:CHEMBL2159536
TypeSmall organic molecule
Emp. Form.C16H20ClN3O2S
Mol. Mass.353.867
SMILESCOc1cc(Cl)cc(CNCCCNC(=O)Nc2ccsc2)c1
Structure
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