Reaction Details |
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Target | Methionine--tRNA ligase, cytoplasmic |
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Ligand | BDBM50393800 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_854755 (CHEMBL2161886) |
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IC50 | 6591±n/a nM |
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Citation | Shibata, S; Gillespie, JR; Ranade, RM; Koh, CY; Kim, JE; Laydbak, JU; Zucker, FH; Hol, WG; Verlinde, CL; Buckner, FS; Fan, E Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. J Med Chem55:6342-51 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Methionine--tRNA ligase, cytoplasmic |
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Name: | Methionine--tRNA ligase, cytoplasmic |
Synonyms: | MARS | MARS1 | Methionyl-tRNA synthetase | SYMC_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 101110.04 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_105283 |
Residue: | 900 |
Sequence: | MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLF
STSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRA
LTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQE
PCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAW
EKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRL
RQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTP
QQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDK
CGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQF
ITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWW
KNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGV
GVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMF
VSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQ
VNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSI
LLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQ
QIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
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BDBM50393800 |
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n/a |
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Name | BDBM50393800 |
Synonyms: | CHEMBL2159536 |
Type | Small organic molecule |
Emp. Form. | C16H20ClN3O2S |
Mol. Mass. | 353.867 |
SMILES | COc1cc(Cl)cc(CNCCCNC(=O)Nc2ccsc2)c1 |
Structure |
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