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TargetMethionine--tRNA ligase, cytoplasmic
LigandBDBM50393800
Substrate/Competitorn/a
Meas. Tech.ChEMBL_854755 (CHEMBL2161886)
IC50 6591±n/a nM
Citation Shibata, SGillespie, JRRanade, RMKoh, CYKim, JELaydbak, JUZucker, FHHol, WGVerlinde, CLBuckner, FSFan, E Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. J Med Chem55:6342-51 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methionine--tRNA ligase, cytoplasmic
Name:Methionine--tRNA ligase, cytoplasmic
Synonyms:MARS | MARS1 | Methionyl-tRNA synthetase | SYMC_HUMAN
Type:PROTEIN
Mol. Mass.:101110.04
Organism:Homo sapiens (Human)
Description:ChEMBL_105283
Residue:900
Sequence:
MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLF
STSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRA
LTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQE
PCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAW
EKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRL
RQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTP
QQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDK
CGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQF
ITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWW
KNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGV
GVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMF
VSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQ
VNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSI
LLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQ
QIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
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BDBM50393800
n/a
NameBDBM50393800
Synonyms:CHEMBL2159536
TypeSmall organic molecule
Emp. Form.C16H20ClN3O2S
Mol. Mass.353.867
SMILESCOc1cc(Cl)cc(CNCCCNC(=O)Nc2ccsc2)c1
Structure
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