| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 3 |
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| Ligand | BDBM50394121 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_856369 |
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| Ki | 5.01±n/a nM |
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| Citation |  Bahl A; Barton P; Bowers K; Caffrey MV; Denton R; Gilmour P; Hawley S; Linannen T; Luckhurst CA; Mochel T; Perry MW; Riley RJ; Roe E; Springthorpe B; Stein L; Webborn P Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092. Bioorg Med Chem Lett 22:6694-9 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 3 |
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| Name: | C-C chemokine receptor type 3 |
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| Synonyms: | C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CD_antigen=CD193 | CKR3 | Eosinophil eotaxin receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 41053.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51677 |
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| Residue: | 355 |
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| Sequence: | MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILI
KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE
TLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRL
IFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVI
YAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
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| BDBM50394121 |
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| n/a |
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| Name | BDBM50394121 |
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| Synonyms: | CHEMBL2158779 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H31Cl2FN2O3 |
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| Mol. Mass. | 509.44 |
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| SMILES | OC(=O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(CC2)Oc2ccc(Cl)cc2Cl)CC1 |r| |
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| Structure | 
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