Reaction Details |
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Target | Hexokinase-4 |
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Ligand | BDBM50394681 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_858381 (CHEMBL2168596) |
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EC50 | 6900±n/a nM |
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Citation | Pfefferkorn, JA; Guzman-Perez, A; Litchfield, J; Aiello, R; Treadway, JL; Pettersen, J; Minich, ML; Filipski, KJ; Jones, CS; Tu, M; Aspnes, G; Risley, H; Bian, J; Stevens, BD; Bourassa, P; D'Aquila, T; Baker, L; Barucci, N; Robertson, AS; Bourbonais, F; Derksen, DR; Macdougall, M; Cabrera, O; Chen, J; Lapworth, AL; Landro, JA; Zavadoski, WJ; Atkinson, K; Haddish-Berhane, N; Tan, B; Yao, L; Kosa, RE; Varma, MV; Feng, B; Duignan, DB; El-Kattan, A; Murdande, S; Liu, S; Ammirati, M; Knafels, J; Dasilva-Jardine, P; Sweet, L; Liras, S; Rolph, TP Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus. J Med Chem55:1318-33 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hexokinase-4 |
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Name: | Hexokinase-4 |
Synonyms: | Gck | HXK4_RAT | Hexokinase type IV |
Type: | PROTEIN |
Mol. Mass.: | 52101.81 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1279785 |
Residue: | 465 |
Sequence: | MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNN
IVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGE
LVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPS
VTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ
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BDBM50394681 |
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n/a |
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Name | BDBM50394681 |
Synonyms: | CHEMBL2165620 |
Type | Small organic molecule |
Emp. Form. | C18H19F3N4O3 |
Mol. Mass. | 396.3637 |
SMILES | OC(=O)c1ccc(NC(=O)[C@H](CC2CCCC2)n2cnc(c2)C(F)(F)F)nc1 |r| |
Structure |
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