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TargetHexokinase-4
LigandBDBM50394689
Substrate/Competitorn/a
Meas. Tech.ChEMBL_858378 (CHEMBL2168593)
EC50>10000±n/a nM
Citation Pfefferkorn, JAGuzman-Perez, ALitchfield, JAiello, RTreadway, JLPettersen, JMinich, MLFilipski, KJJones, CSTu, MAspnes, GRisley, HBian, JStevens, BDBourassa, PD'Aquila, TBaker, LBarucci, NRobertson, ASBourbonais, FDerksen, DRMacdougall, MCabrera, OChen, JLapworth, ALLandro, JAZavadoski, WJAtkinson, KHaddish-Berhane, NTan, BYao, LKosa, REVarma, MVFeng, BDuignan, DBEl-Kattan, AMurdande, SLiu, SAmmirati, MKnafels, JDasilva-Jardine, PSweet, LLiras, SRolph, TP Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus. J Med Chem55:1318-33 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hexokinase-4
Name:Hexokinase-4
Synonyms:GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:Enzyme
Mol. Mass.:52175.81
Organism:Homo sapiens (Human)
Description:P35557
Residue:465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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  Blast E-value cutoff:
BDBM50394689
n/a
NameBDBM50394689
Synonyms:CHEMBL2165625
TypeSmall organic molecule
Emp. Form.C17H20F3N4O4P
Mol. Mass.432.3341
SMILESOP(O)(=O)c1ccc(NC(=O)[C@H](CC2CCCC2)n2cnc(c2)C(F)(F)F)nc1 |r|
Structure
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