Reaction Details |
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Target | Histamine H2 receptor |
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Ligand | BDBM50394699 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_858644 (CHEMBL2166526) |
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EC50 | 0.832±n/a nM |
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Citation | Birnkammer, T; Spickenreither, A; Brunskole, I; Lopuch, M; Kagermeier, N; Bernhardt, G; Dove, S; Seifert, R; Elz, S; Buschauer, A The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists. J Med Chem55:1147-60 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H2 receptor |
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Name: | Histamine H2 receptor |
Synonyms: | Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40567.22 |
Organism: | Cavia porcellus (domestic guinea pig) |
Description: | For the H2 receptor-binding assays, guinea pig striatum was used. |
Residue: | 359 |
Sequence: | MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSL
AVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVM
GAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYH
QLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
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BDBM50394699 |
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n/a |
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Name | BDBM50394699 |
Synonyms: | CHEMBL2165631 |
Type | Small organic molecule |
Emp. Form. | C25H42N10O2S2 |
Mol. Mass. | 578.797 |
SMILES | Cc1nc(N)sc1CCCNC(=N)NC(=O)CCCCCCCC(=O)NC(=N)NCCCc1sc(N)nc1C |
Structure |
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