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TargetHistamine H2 receptor
LigandBDBM50394714
Substrate/Competitorn/a
Meas. Tech.ChEMBL_858640 (CHEMBL2166522)
EC50 15.85±n/a nM
Citation Birnkammer, TSpickenreither, ABrunskole, ILopuch, MKagermeier, NBernhardt, GDove, SSeifert, RElz, SBuschauer, A The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists. J Med Chem55:1147-60 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H2 receptor
Name:Histamine H2 receptor
Synonyms:Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40567.22
Organism:Cavia porcellus (domestic guinea pig)
Description:For the H2 receptor-binding assays, guinea pig striatum was used.
Residue:359
Sequence:
MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSL
AVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVM
GAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYH
QLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50394714
n/a
NameBDBM50394714
Synonyms:CHEMBL2165646
TypeSmall organic molecule
Emp. Form.C17H23N5OS
Mol. Mass.345.462
SMILESCc1nc(N)sc1CCCN=C(N)NC(=O)CCc1ccccc1 |w:10.10|
Structure
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