| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adenosine receptor A2a |
|---|
| Ligand | BDBM50316876 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_858812 (CHEMBL2167687) |
|---|
| Ki | 8.2±n/a nM |
|---|
| Citation |  Shook, BC; Rassnick, S; Wallace, N; Crooke, J; Ault, M; Chakravarty, D; Barbay, JK; Wang, A; Powell, MT; Leonard, K; Alford, V; Scannevin, RH; Carroll, K; Lampron, L; Westover, L; Lim, HK; Russell, R; Branum, S; Wells, KM; Damon, S; Youells, S; Li, X; Beauchamp, DA; Rhodes, K; Jackson, PF Design and characterization of optimized adenosine A2A/A1 receptor antagonists for the treatment of Parkinson's disease. J Med Chem55:1402-17 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adenosine receptor A2a |
|---|
| Name: | Adenosine receptor A2a |
|---|
| Synonyms: | A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 44716.46 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29274 |
|---|
| Residue: | 412 |
|---|
| Sequence: | MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
|
|
|
|---|
| BDBM50316876 |
|---|
| n/a |
|---|
| Name | BDBM50316876 |
|---|
| Synonyms: | 2-amino-8-(4-methylpiperazine-1-carbonyl)-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one | CHEMBL1087185 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H21N5O2 |
|---|
| Mol. Mass. | 399.4451 |
|---|
| SMILES | CN1CCN(CC1)C(=O)c1ccc2C(=O)c3c(nc(N)nc3-c3ccccc3)-c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
