Reaction Details |
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Target | Aurora kinase C |
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Ligand | BDBM50394779 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_859557 (CHEMBL2168186) |
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Kd | <10±n/a nM |
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Citation | Liu, G; Abraham, S; Tran, L; Vickers, TD; Xu, S; Hadd, MJ; Quiambao, S; Holladay, MW; Hua, H; Ford Pulido, JM; Gunawardane, RN; Davis, MI; Eichelberger, SR; Apuy, JL; Gitnick, D; Gardner, MF; James, J; Breider, MA; Belli, B; Armstrong, RC; Treiber, DK Discovery of highly potent and selective pan-Aurora kinase inhibitors with enhanced in vivo antitumor therapeutic index. J Med Chem55:3250-60 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase C |
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Name: | Aurora kinase C |
Synonyms: | AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C |
Type: | Enzyme |
Mol. Mass.: | 35602.43 |
Organism: | Homo sapiens (Human) |
Description: | Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system. |
Residue: | 309 |
Sequence: | MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
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BDBM50394779 |
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n/a |
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Name | BDBM50394779 |
Synonyms: | CHEMBL2163394 |
Type | Small organic molecule |
Emp. Form. | C28H33N9O2S |
Mol. Mass. | 559.686 |
SMILES | Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@H](C4)C(=O)NC4CCCC4)cc3)nn3cccc23)n[nH]1 |r| |
Structure |
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