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TargetCeramide glucosyltransferase
LigandBDBM50394815
Substrate/Competitorn/a
Meas. Tech.ChEMBL_859947 (CHEMBL2167350)
IC50 7±n/a nM
Citation Richards, SLarson, CJKoltun, ESHanel, AChan, VNachtigall, JHarrison, AAay, NDu, HArcalas, AGalan, AZhang, JZhang, WWon, KATam, DQian, FWang, TFinn, POgilvie, KRosen, JAoyama, RPlonowski, ACancilla, BBentzien, FYakes, MMohan, RLamb, PNuss, JKearney, P Discovery and characterization of an inhibitor of glucosylceramide synthase. J Med Chem55:4322-35 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ceramide glucosyltransferase
Name:Ceramide glucosyltransferase
Synonyms:CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG
Type:PROTEIN
Mol. Mass.:44859.25
Organism:Homo sapiens (Human)
Description:ChEMBL_1435474
Residue:394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
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  Blast E-value cutoff:
BDBM50394815
n/a
NameBDBM50394815
Synonyms:CHEMBL2163834
TypeSmall organic molecule
Emp. Form.C24H26BrCl2N3O2
Mol. Mass.539.292
SMILESCN1CCN(CC1)C(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)C1(CC1)c1ccc(Cl)cc1Cl |r|
Structure
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