| Reaction Details |
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 | Report a problem with these data |
| Target | Homo sapiens lysine demethylase 2A (KDM2A) |
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| Ligand | BDBM50395076 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_859422 |
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| Ki | 1970±n/a nM |
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| Citation |  Rose NR; Woon EC; Tumber A; Walport LJ; Chowdhury R; Li XS; King ON; Lejeune C; Ng SS; Krojer T; Chan MC; Rydzik AM; Hopkinson RJ; Che KH; Daniel M; Strain-Damerell C; Gileadi C; Kochan G; Leung IK; Dunford J; Yeoh KK; Ratcliffe PJ; Burgess-Brown N; von Delft F; Muller S; Marsden B; Brennan PE; McDonough MA; Oppermann U; Klose RJ; Schofield CJ; Kawamura A Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem 55:6639-43 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Homo sapiens lysine demethylase 2A (KDM2A) |
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| Name: | Homo sapiens lysine demethylase 2A (KDM2A) |
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| Synonyms: | AA1-1162 | F-box and leucine-rich repeat protein 11 | FBXL11 | Lysine-specific demethylase 2A | Lysine-specific demethylase 2A (KDM2A) | NM_012308 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 132809.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 1162 |
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| Sequence: | MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGK
DFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIE
MTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES
QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHN
LELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFL
HSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS
MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKT
LAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPT
GIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKP
HTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRM
KQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEG
LLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPT
SMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNP
SGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHC
PARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMS
VFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLS
WTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIR
DLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQ
SSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHF
ISDLSINSLYCLSDEKLIQKIS
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| BDBM50395076 |
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| n/a |
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| Name | BDBM50395076 |
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| Synonyms: | CHEMBL2164243 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H12N2O3 |
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| Mol. Mass. | 160.1711 |
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| SMILES | CN(C)NC(=O)CCC(O)=O |
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| Structure | 
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