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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Egl nine homolog 1 | ||
| Ligand | BDBM50129197 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_859438 | ||
| IC50 | 19600±n/a nM | ||
| Citation |  Rose NR; Woon EC; Tumber A; Walport LJ; Chowdhury R; Li XS; King ON; Lejeune C; Ng SS; Krojer T; Chan MC; Rydzik AM; Hopkinson RJ; Che KH; Daniel M; Strain-Damerell C; Gileadi C; Kochan G; Leung IK; Dunford J; Yeoh KK; Ratcliffe PJ; Burgess-Brown N; von Delft F; Muller S; Marsden B; Brennan PE; McDonough MA; Oppermann U; Klose RJ; Schofield CJ; Kawamura A Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem 55:6639-43 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Egl nine homolog 1 | |||
| Name: | Egl nine homolog 1 | ||
| Synonyms: | Egl nine homolog 1 (EGLIN1) | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2) | ||
| Type: | Protein | ||
| Mol. Mass.: | 46035.59 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9GZT9 | ||
| Residue: | 426 | ||
| Sequence: |
| ||
| BDBM50129197 | |||
| n/a | |||
| Name | BDBM50129197 | ||
| Synonyms: | 4-(Hydroxyamino)-4-oxobutanoic acid | CHEMBL51979 | N-Hydroxy-succinamic acid | ||
| Type | Small organic molecule | ||
| Emp. Form. | C4H7NO4 | ||
| Mol. Mass. | 133.1027 | ||
| SMILES | ONC(=O)CCC(O)=O | ||
| Structure | 
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