Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetKappa-type opioid receptor
LigandBDBM50395115
Substrate/Competitorn/a
Meas. Tech.ChEMBL_859459
Ki 0.52±n/a nM
Citation Majumdar SSubrath JLe Rouzic VPolikar LBurgman MNagakura KOcampo JHaselton NPasternak ARGrinnell SPan YXPasternak GW Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associatedµ opioid receptor (MOR-1) splice variants. J Med Chem 55:6352-62 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kappa-type opioid receptor
Name:Kappa-type opioid receptor
Synonyms:KOR-1 | MSL-1 | OPIATE Kappa | OPRK1
Type:Enzyme
Mol. Mass.:42656.78
Organism:Mus musculus (Mouse)
Description:P33534
Residue:380
Sequence:
MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRV
RNTVQDPASMRDVGGMNKPV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50395115
n/a
NameBDBM50395115
Synonyms:CHEMBL2163538
TypeSmall organic molecule
Emp. Form.C26H27ClN2O4
Mol. Mass.466.957
SMILESOc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)NC(=O)c1cccc(Cl)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: