| Reaction Details |
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 | Report a problem with these data |
| Target | Transcriptional regulator ERG |
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| Ligand | BDBM50395256 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_860183 (CHEMBL2168923) |
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| IC50 | >100000±n/a nM |
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| Citation |  Dossetter, AG; Beeley, H; Bowyer, J; Cook, CR; Crawford, JJ; Finlayson, JE; Heron, NM; Heyes, C; Highton, AJ; Hudson, JA; Jestel, A; Kenny, PW; Krapp, S; Martin, S; MacFaul, PA; McGuire, TM; Gutierrez, PM; Morley, AD; Morris, JJ; Page, KM; Ribeiro, LR; Sawney, H; Steinbacher, S; Smith, C; Vickers, M (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis. J Med Chem55:6363-74 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcriptional regulator ERG |
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| Name: | Transcriptional regulator ERG |
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| Synonyms: | ERG | ERG_HUMAN | Transforming protein ERG |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54615.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1335569 |
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| Residue: | 486 |
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| Sequence: | MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ
QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM
PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK
DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN
TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY
QILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGE
RKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPS
DLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPS
HLGTYY
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| BDBM50395256 |
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| n/a |
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| Name | BDBM50395256 |
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| Synonyms: | CHEMBL2163587 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28N4O3 |
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| Mol. Mass. | 420.5041 |
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| SMILES | COc1cccc2c3CN(CCc3[nH]c12)C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(CC1)C#N |r| |
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| Structure | 
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