Reaction Details | |||
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Target | Potassium voltage-gated channel subfamily KQT member 2 | ||
Ligand | BDBM50395477 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_858529 (CHEMBL2169533) | ||
IC50 | >30000±n/a nM | ||
Citation | Cheung, YY; Yu, H; Xu, K; Zou, B; Wu, M; McManus, OB; Li, M; Lindsley, CW; Hopkins, CR Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor. J Med Chem55:6975-9 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Potassium voltage-gated channel subfamily KQT member 2 | |||
Name: | Potassium voltage-gated channel subfamily KQT member 2 | ||
Synonyms: | KCNQ (Kv7) potassium channel | KCNQ2 | KCNQ2_HUMAN | KQT-like 2 | Neuroblastoma-specific potassium channel subunit alpha KvLQT2 | Potassium voltage-gated channel subfamily KQT member 2 | Voltage-gated potassium channel subunit Kv7.2 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 95883.20 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1457496 | ||
Residue: | 872 | ||
Sequence: |
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BDBM50395477 | |||
n/a | |||
Name | BDBM50395477 | ||
Synonyms: | CHEMBL2163679 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H20N2O3 | ||
Mol. Mass. | 336.3844 | ||
SMILES | CCC(C(=O)Nc1ccccc1-n1c(O)ccc1O)c1ccccc1 |(13.24,-55.63,;12.47,-54.3,;10.93,-54.3,;10.16,-52.96,;10.93,-51.64,;8.62,-52.96,;7.85,-51.64,;8.62,-50.3,;7.85,-48.97,;6.31,-48.97,;5.54,-50.3,;6.31,-51.64,;5.54,-52.96,;5.97,-54.44,;7.41,-54.97,;4.69,-55.31,;3.48,-54.36,;4.01,-52.92,;3.15,-51.63,;10.16,-55.63,;8.62,-55.63,;7.85,-56.96,;8.62,-58.3,;10.16,-58.3,;10.93,-56.96,)| | ||
Structure |