Reaction Details |
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Target | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
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Ligand | BDBM50395537 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_858722 (CHEMBL2167033) |
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IC50 | 6.31±n/a nM |
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Citation | Liddle, J; Bamborough, P; Barker, MD; Campos, S; Chung, CW; Cousins, RP; Faulder, P; Heathcote, ML; Hobbs, H; Holmes, DS; Ioannou, C; Ramirez-Molina, C; Morse, MA; Osborn, R; Payne, JJ; Pritchard, JM; Rumsey, WL; Tape, DT; Vicentini, G; Whitworth, C; Williamson, RA 4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy. Bioorg Med Chem Lett22:5222-6 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Inhibitor of nuclear factor kappa-B kinase subunit alpha |
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Name: | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
Synonyms: | CHUK | Conserved helix-loop-helix ubiquitous kinase | I-kappa-B kinase 1 | I-kappa-B kinase alpha | IKK-A | IKK-alpha | IKK1 | IKK2/IKK1 | IKKA | IKKA_HUMAN | IkBKA | IkappaB kinase | Inhibitor of NF-kappa-B kinase alpha/beta | NFKBIKA | Nuclear factor NF-kappa-B inhibitor kinase alpha | TCF-16 | TCF16 | Transcription factor 16 |
Type: | PROTEIN |
Mol. Mass.: | 84642.21 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_327453 |
Residue: | 745 |
Sequence: | MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHL
STIIHEANEEQGNSMMNLDWSWLTE
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BDBM50395537 |
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n/a |
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Name | BDBM50395537 |
Synonyms: | CHEMBL2164411 |
Type | Small organic molecule |
Emp. Form. | C21H25N3O4S2 |
Mol. Mass. | 447.571 |
SMILES | CC(C)c1cc2c(ccnc2[nH]1)-c1ccc(cc1)S(=O)(=O)NC1CCS(=O)(=O)CC1 |
Structure |
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