| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2C9 |
|---|
| Ligand | BDBM50395799 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_860474 (CHEMBL2166643) |
|---|
| IC50 | >50000±n/a nM |
|---|
| Citation |  Surivet, JP; Lange, R; Hubschwerlen, C; Keck, W; Specklin, JL; Ritz, D; Bur, D; Locher, H; Seiler, P; Strasser, DS; Prade, L; Kohl, C; Schmitt, C; Chapoux, G; Ilhan, E; Ekambaram, N; Athanasiou, A; Knezevic, A; Sabato, D; Chambovey, A; Gaertner, M; Enderlin, M; Boehme, M; Sippel, V; Wyss, P Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity. Bioorg Med Chem Lett22:6705-11 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2C9 |
|---|
| Name: | Cytochrome P450 2C9 |
|---|
| Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | CP2C9_HUMAN | CYP2C10 | CYP2C9 | CYPIIC9 | Cytochrome P450 2C9 (CYP2C9 ) | Cytochrome P450 2C9 (CYP2C9) | P-450MP | P450 MP-4/MP-8 | P450 PB-1 | S-mephenytoin 4-hydroxylase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55636.33 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11712 |
|---|
| Residue: | 490 |
|---|
| Sequence: | MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
|
|
|
|---|
| BDBM50395799 |
|---|
| n/a |
|---|
| Name | BDBM50395799 |
|---|
| Synonyms: | CHEMBL2163365 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H6BrF3N4O |
|---|
| Mol. Mass. | 335.08 |
|---|
| SMILES | NC(=O)c1cc2cc(Br)c(nc2nc1N)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
