| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein kinase C epsilon type |
|---|
| Ligand | BDBM50395892 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_858038 (CHEMBL2166774) |
|---|
| Ki | >1000000±n/a nM |
|---|
| Citation |  Tell, V; Holzer, M; Herrmann, L; Mahmoud, KA; Schächtele, C; Totzke, F; Hilgeroth, A Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases. Bioorg Med Chem Lett22:6914-8 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein kinase C epsilon type |
|---|
| Name: | Protein kinase C epsilon type |
|---|
| Synonyms: | KPCE_HUMAN | PKC epsilon | PKCE | PRKCE | Protein kinase C epsilon | Protein kinase C epsilon type | Protein kinase C, PKC; classical/novel | Protein kinase C, epsilon | nPKC-epsilon |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 83680.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
|---|
| Residue: | 737 |
|---|
| Sequence: | MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT
NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE
PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP
TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN
MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA
KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE
NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG
KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD
RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL
DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM
MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED
AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI
NQEEFKGFSYFGEDLMP
|
|
|
|---|
| BDBM50395892 |
|---|
| n/a |
|---|
| Name | BDBM50395892 |
|---|
| Synonyms: | CHEMBL2163772 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H11NO3 |
|---|
| Mol. Mass. | 277.2741 |
|---|
| SMILES | Oc1ccc2oc3ncc(O)c(-c4ccccc4)c3c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
