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TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase
LigandBDBM50395904
Substrate/Competitorn/a
Meas. Tech.ChEMBL_858075
IC50 4.71±n/a nM
Citation McAllister LAMontgomery JIAbramite JAReilly UBrown MFChen JMBarham RAChe YChung SWMenard CAMitton-Fry MMullins LMNoe MCO'Donnell JPOliver RMPenzien JBPlummer MPrice LMShanmugasundaram VTomaras APUccello DP Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents. Bioorg Med Chem Lett 22:6832-8 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Name:UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:lpxC
Type:PROTEIN
Mol. Mass.:21890.40
Organism:Pseudomonas aeruginosa
Description:ChEMBL_858075
Residue:197
Sequence:
TVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKRE
VSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFM
RDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLI
GEFRGFKSGHALNNQLL
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BDBM50395904
n/a
NameBDBM50395904
Synonyms:CHEMBL2164185
TypeSmall organic molecule
Emp. Form.C15H19ClN4O5S
Mol. Mass.402.853
SMILESCOc1ccc(-c2cn(CC[C@](C)(C(=O)NO)S(C)(=O)=O)nn2)c(Cl)c1 |r|
Structure
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