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TargetMuscarinic acetylcholine receptor M1
LigandBDBM50395974
Substrate/Competitorn/a
Meas. Tech.ChEMBL_858567
IC50 95.5±n/a nM
Citation Poslusney MSSevel CUtley TJBridges TMMorrison RDKett NRSheffler DJNiswender CMDaniels JSConn PJLindsley CWWood MR Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists. Bioorg Med Chem Lett 22:6923-8 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M1
Name:Muscarinic acetylcholine receptor M1 and M3
Synonyms:CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:Protein
Mol. Mass.:51442.54
Organism:Homo sapiens (Human)
Description:P11229
Residue:460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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  Blast E-value cutoff:
BDBM50395974
n/a
NameBDBM50395974
Synonyms:CHEMBL2164894
TypeSmall organic molecule
Emp. Form.C21H26N2O
Mol. Mass.322.4439
SMILESCN1CCCN(CC1)C(=O)C(Cc1ccccc1)c1ccccc1
Structure
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