| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM50395999 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_858567 (CHEMBL2166012) |
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| IC50 | 180±n/a nM |
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| Citation |  Poslusney, MS; Sevel, C; Utley, TJ; Bridges, TM; Morrison, RD; Kett, NR; Sheffler, DJ; Niswender, CM; Daniels, JS; Conn, PJ; Lindsley, CW; Wood, MR Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists. Bioorg Med Chem Lett22:6923-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 |
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| Type: | Protein |
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| Mol. Mass.: | 51442.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11229 |
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| Residue: | 460 |
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| Sequence: | MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM50395999 |
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| n/a |
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| Name | BDBM50395999 |
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| Synonyms: | CHEMBL1426275 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N2O |
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| Mol. Mass. | 306.4015 |
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| SMILES | CN1CCN(CC1)C(=O)C(=C/c1ccccc1)\c1ccccc1 |
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| Structure | 
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