| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase E(z) |
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| Ligand | BDBM50315537 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_861239 (CHEMBL2173377) |
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| IC50 | >90000±n/a nM |
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| Citation |  Decarlo, D; Hadden, MK Oncoepigenomics: making histone lysine methylation count. Eur J Med Chem56:179-194 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase E(z) |
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| Name: | Histone-lysine N-methyltransferase E(z) |
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| Synonyms: | E(z) | EZ_DROME | KMT6 | Lysine N-methyltransferase 6 | Protein enhancer of zeste |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86931.57 |
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| Organism: | Drosophila melanogaster |
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| Description: | ChEMBL_861239 |
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| Residue: | 760 |
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| Sequence: | MNSTKVPPEWKRRVKSEYIKIRQQKRYKRADEIKEAWIRNWDEHNHNVQDLYCESKVWQA
KPYDPPHVDCVKRAEVTSYNGIPSGPQKVPICVINAVTPIPTMYTWAPTQQNFMVEDETV
LHNIPYMGDEVLDKDGKFIEELIKNYDGKVHGDKDPSFMDDAIFVELVHALMRSYSKELE
EAAPGTATAIKTETLAKSKQGEDDGVVDVDADGESPMKLEKTDSKGDLTEVEKKETEEPL
ETEDADVKPDVEEVKDKLPFPAPIIFQAISANFPDKGTAQELKEKYIELTEHQDPERPQE
CTPNIDGIKAESVSRERTMHSFHTLFCRRCFKYDCFLHRLQGHAGPNLQKRRYPELKPFA
EPCSNSCYMLIDGMKEKLAADSKTPPIDSCNEASSEDSNDSNSQFSNKDFNHENSKDNGL
TVNSAAVAEINSIMAGMMNITSTQCVWTGADQALYRVLHKVYLKNYCAIAHNMLTKTCRQ
VYEFAQKEDAEFSFEDLRQDFTPPRKKKKKQRLWSLHCRKIQLKKDSSSNHVYNYTPCDH
PGHPCDMNCSCIQTQNFCEKFCNCSSDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLC
QACGADQFKLTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEII
SQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDH
RIGIFAKRAIQPGEELFFDYRYGPTEQLKFVGIEREMEIV
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| BDBM50315537 |
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| n/a |
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| Name | BDBM50315537 |
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| Synonyms: | CHEMBL1089316 | chaetocin |
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| Type | Small organic molecule |
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| Emp. Form. | C30H28N6O6S4 |
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| Mol. Mass. | 696.84 |
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| SMILES | CN1C(=O)[C@@]23C[C@]4([C@H](Nc5ccccc45)N2C(=O)[C@]1(CO)SS3)[C@]12C[C@]34SS[C@](CO)(N(C)C3=O)C(=O)N4[C@H]1Nc1ccccc21 |r,THB:36:35:31.33:26.27,7:15:1.2:22.21,38:37:31.33:26.27,17:16:1.2:22.21| |
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| Structure | 
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