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TargetHistone-lysine N-methyltransferase E(z)
LigandBDBM50315537
Substrate/Competitorn/a
Meas. Tech.ChEMBL_861239
IC50>90000±n/a nM
Citation Decarlo DHadden MK Oncoepigenomics: making histone lysine methylation count. Eur J Med Chem 56:179-194 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone-lysine N-methyltransferase E(z)
Name:Histone-lysine N-methyltransferase E(z)
Synonyms:E(z) | KMT6 | Lysine N-methyltransferase 6 | Protein enhancer of zeste
Type:PROTEIN
Mol. Mass.:86931.57
Organism:Drosophila melanogaster
Description:ChEMBL_861239
Residue:760
Sequence:
MNSTKVPPEWKRRVKSEYIKIRQQKRYKRADEIKEAWIRNWDEHNHNVQDLYCESKVWQA
KPYDPPHVDCVKRAEVTSYNGIPSGPQKVPICVINAVTPIPTMYTWAPTQQNFMVEDETV
LHNIPYMGDEVLDKDGKFIEELIKNYDGKVHGDKDPSFMDDAIFVELVHALMRSYSKELE
EAAPGTATAIKTETLAKSKQGEDDGVVDVDADGESPMKLEKTDSKGDLTEVEKKETEEPL
ETEDADVKPDVEEVKDKLPFPAPIIFQAISANFPDKGTAQELKEKYIELTEHQDPERPQE
CTPNIDGIKAESVSRERTMHSFHTLFCRRCFKYDCFLHRLQGHAGPNLQKRRYPELKPFA
EPCSNSCYMLIDGMKEKLAADSKTPPIDSCNEASSEDSNDSNSQFSNKDFNHENSKDNGL
TVNSAAVAEINSIMAGMMNITSTQCVWTGADQALYRVLHKVYLKNYCAIAHNMLTKTCRQ
VYEFAQKEDAEFSFEDLRQDFTPPRKKKKKQRLWSLHCRKIQLKKDSSSNHVYNYTPCDH
PGHPCDMNCSCIQTQNFCEKFCNCSSDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLC
QACGADQFKLTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEII
SQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDH
RIGIFAKRAIQPGEELFFDYRYGPTEQLKFVGIEREMEIV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50315537
n/a
NameBDBM50315537
Synonyms:CHEMBL1089316 | chaetocin
TypeSmall organic molecule
Emp. Form.C30H28N6O6S4
Mol. Mass.696.84
SMILESCN1C(=O)[C@@]23C[C@]4([C@H](Nc5ccccc45)N2C(=O)[C@]1(CO)SS3)[C@]12C[C@]34SS[C@](CO)(N(C)C3=O)C(=O)N4[C@H]1Nc1ccccc21 |r,THB:36:35:31.33:26.27,7:15:1.2:22.21,38:37:31.33:26.27,17:16:1.2:22.21|
Structure
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