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TargetChloroquine resistance transporter
LigandBDBM50396333
Substrate/Competitorn/a
Meas. Tech.ChEMBL_864478 (CHEMBL2176281)
IC50 10500±n/a nM
Citation Gemma, SCamodeca, CSanna Coccone, SJoshi, BPBernetti, MMoretti, VBrogi, SBonache de Marcos, MCSavini, LTaramelli, DBasilico, NParapini, SRottmann, MBrun, RLamponi, SCaccia, SGuiso, GSummers, RLMartin, RESaponara, SGorelli, BNovellino, ECampiani, GButini, S Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. J Med Chem55:6948-67 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Chloroquine resistance transporter
Name:Chloroquine resistance transporter
Synonyms:CRT | CRT_PLAFA | PfCRT
Type:PROTEIN
Mol. Mass.:48687.29
Organism:Plasmodium falciparum
Description:ChEMBL_1364181
Residue:424
Sequence:
MKFASKKNNQKNSSKNDERYRELDNLVQEGNGSRLGGGSCLGKCAHVFKLIFKEIKDNIF
IYILSIIYLSVCVMNKIFAKRTLNKIGNYSFVTSETHNFICMIMFFIVYSLFGNKKGNSK
ERHRSFNLQFFAISMLDACSVILAFIGLTRTTGNIQSFVLQLSIPINMFFCFLILRYRYH
LYNYLGAVIIVVTIALVEMKLSFETQEENSIIFNLVLISALIPVCFSNMTREIVFKKYKI
DILRLNAMVSFFQLFTSCLILPVYTLPFLKQLHLPYNEIWTNIKNGFACLFLGRNTVVEN
CGLGMAKLCDDCDGAWKTFALFSFFNICDNLITSYIIDKFSTMTYTIVSCIQGPAIAIAY
YFKFLAGDVVREPRLLDFVTLFGYLFGSIIYRVGNIILERKKMRNEENEDSEGELTNVDS
IITQ
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BDBM50396333
n/a
NameBDBM50396333
Synonyms:CHEMBL2170036
TypeSmall organic molecule
Emp. Form.C27H26Cl2N4
Mol. Mass.477.428
SMILESClc1cccc(c1)C(Nc1ccnc2cc(Cl)ccc12)c1ccc(CN2CCNCC2)cc1
Structure
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