Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetRAF proto-oncogene serine/threonine-protein kinase
LigandBDBM35327
Substrate/Competitorn/a
Meas. Tech.ChEMBL_862423
Ki 0.30±n/a nM
Citation Wang XKim J Conformation-specific effects of Raf kinase inhibitors. J Med Chem 55:7332-41 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RAF proto-oncogene serine/threonine-protein kinase
Name:BRAF/CRAF
Synonyms:C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | Serine/threonine-protein kinase C-Raf | Serine/threonine-protein kinase RAF | cRaf
Type:Serine/threonine-protein kinase
Mol. Mass.:73082.52
Organism:Homo sapiens (Human)
Description:n/a
Residue:648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM35327
n/a
NameBDBM35327
Synonyms:pyridylpurine aminoisoquinoline, 1
TypeSmall organic molecule
Emp. Form.C26H19ClN8
Mol. Mass.478.936
SMILESCc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ncnc2nc[nH]c12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: