Reaction Details |
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Target | 7-dehydrocholesterol reductase |
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Ligand | BDBM50170646 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_864350 (CHEMBL2175827) |
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IC50 | 500±n/a nM |
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Citation | Horling, A; Müller, C; Barthel, R; Bracher, F; Imming, P A new class of selective and potent 7-dehydrocholesterol reductase inhibitors. J Med Chem55:7614-22 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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7-dehydrocholesterol reductase |
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Name: | 7-dehydrocholesterol reductase |
Synonyms: | 7-DHC reductase | 7-dehydrocholesterol reductase | Anti-estrogen binding site (AEBS) | D7SR | DHCR7 | DHCR7_HUMAN | Putative sterol reductase SR-2 | Sterol Delta(7)-reductase |
Type: | PROTEIN |
Mol. Mass.: | 54508.42 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_864350 |
Residue: | 475 |
Sequence: | MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
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BDBM50170646 |
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n/a |
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Name | BDBM50170646 |
Synonyms: | 4-(2-{4-[(E)-3-(4-Chloro-phenyl)-allyl]-piperazin-1-yl}-ethyl)-benzoic acid | CHEMBL189871 | CHEMBL2172263 |
Type | Small organic molecule |
Emp. Form. | C22H25ClN2O2 |
Mol. Mass. | 384.899 |
SMILES | OC(=O)c1ccc(CCN2CCN(C\C=C\c3ccc(Cl)cc3)CC2)cc1 |
Structure |
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